If you thought this was just a usual game then you are probably wrong, this is the greatest match ever in the Premier League fixtures since it is a do or die kind of a match.
The Reds visit their bitter adversaries knowing a win will take them three points clear of Man City and act as an enormous mental boost moving forward.
Even a draw is not to be sniffed at, considering their wretched run at Old Trafford, dropped points though it may be.
Liverpool would still jump above City with a point, leaving destiny in their own hands.
We have reached the crunch point of the season, with every match feeling significant, and we are about to learn a lot about the belief that exists in this Liverpool squad.
Waiting for them this weekend are a United side reinvigorated under Ole Gunnar Solskjaer and looking to damage their rivals’ title hopes.
The thought of Liverpool clinching glory is one that will be giving United fans sleepless nights and the players will be chomping at the bit come kickoff.
KloppK must have his team prepared for a cauldron of an atmosphere and a game likely to be as intense as any they have faced in 2018/19.
Win, and it will be one of the Reds’ most significant away results in years. They’re more than capable of it.
Virgil van Dijk returns from suspension after missing Tuesday’s 0-0 draw with Bayern Munich, which is a major plus point.
The Dutchman looks set to partner Joel Matip in the continued absence of Joe Gomez and Dejan Lovren.
There are no other injury concerns, although Alex Oxlade-Chamberlain and Rhian Brewster are still a way off playing first-team football.
In midfield, Klopp has a selection dilemma, with Fabinho sure to go back into the No.6 role, leaving Jordan Henderson, Gini Wijnaldum, Naby Keita and James Milner battling for two starting berths.
Wijnaldum seems a certainty to start, given his form, but the other three could all make strong cases for featuring from the beginning, too.
Fit-again Xherdan Shaqiri is another option should the manager revert to a 4-2-3-1 formation, but that seems unlikely.
Mohamed Salah, Sadio Mane and Roberto Firmino are all primed and raring to go, with the two wide men needing to offer more than they did against Bayern.
United could have Jesse Lingard and Anthony Martial available, having initially been major doubts, but Antonio Valencia, Matteo Darmian and Marcos Rojo will all miss out.
Since 2000, there has only been one draw at Old Trafford in the Premier League match between Man United and Liverpool.