The Gunners, who reached the semi-final stage of the competition last season before coming unstuck against Atletico Madrid, are back in the hunt for major silverware.
Monreal said of the challenges facing Arsenal on the road: “These were the worst teams in the draw, we have two long trips to Azerbaijan and Ukraine.
“But it is not an excuse not to go there, play a good game, good football and get the three points.”
Having fallen agonisingly short in the 2017-18 Europa League, Monreal is determined to go a few steps further this year.
He sees no reason why Arsenal cannot get back on the trophy trail, while also chasing down a route into Champions League competition through their efforts in the Premier League.
The Spanish defender added: “We missed a really good opportunity to win the Europa League.
“We would have qualified automatically for the Champions League and that was our target.