Forwards Eder and Nani were surprise absentees from Portugal’s World Cup squad with national team coach Fernando Santos opting instead for the youth of Andre Silva and Goncalo Guedes to play alongside superstar Cristiano Ronaldo.
Also missing from the 23-man squad was Andre Gomes who, like Eder and Nani, played at the 2016 European championships won by the Portuguese.
Injured Porto midfielder Danilo Pereira was also missing from the line-up.
At 33, five-time Ballon d’Or winner Ronaldo and 34-year-old Ricardo Quaresma are the only players over 30 in the Portuguese attack.
Eder scored the extra-time winning goal in the Euro 2016 final against France but he was desperately out of form for Lokomotiv Moscow this season, scoring just four goals as his club side claimed the Russian Premier League title.
Nani, 31 and his country’s third most-capped player behind Ronaldo and Luis Figo with 112 appearances, has played just 24 matches all season with Lazio.
“From a human perspective, it’s very hard to discard players who were with us at Euro 2016,” admitted 63-year-old coach Santos.