Tottenham and Manchester City is Saturday’s early kick-off.
The two sides will be sick of the sight of each other after this game as it will be their 3rd meeting in the space of two weeks.
Tottenham came out on top in the first meeting at their new stadium, winning 1-0.
Manchester City then beat Spurs 4-3 this past Wednesday in the second leg of their Champions League tie.
However, Spurs still went through to the semi-final on away goals.
Hugo Lloris misses out
Both sides will be desperate for a result on Saturday with City fighting for top spot and Spurs challenging for a Champions League place.
Spurs fans may not be to happy with their teams line-up vs City though.
Hugo Lloris has been completely omitted from the matchday squad due to injury while Juan Foyth is starting at right-back over Kieran Trippier.
Also, for the first time in a while, Vincent Janssen has been put into the Spurs matchday squad.
Twitter reaction
Here is how some fans reacted to Spurs squad.