Chelsea beat Cardiff on Sunday 2-1 in dramatic fashion thanks to late goals from Cesar Azpilicueta and Ruben Loftus-Cheek.
And despite the win, pressure is sure to keep growing on manager Maurizio Sarri, who was the subject of negative chanting by Blues fans during the game.
Sarri could look to freshen up his squad in order to give Chelsea the best chance of staying competitive until the end of the season.
Loftus-Cheek may be in line for a start thanks to his late heroics in Wales.
Callum Hudson-Odoi is expected to start his first game in the league, after Sarri spoke about him on Tuesday.
“In my opinion, he is our future,” Sarri said.
“He will probably start tomorrow or in the next match.”
The 18-year-old has played 19 times for Chelsea this season and has scored five goals.
Ross Barkley may continue in the starting line-up thanks to some recent good form for club and country.
N’Golo Kante should also come back into the fold for Chelsea, having sat out the win over Cardiff, with Eden Hazard to start too.
Chelsea are currently sixth in the Premier League, a point behind Manchester United and Tottenham while the Blues sit 19 points behind table-toppers Liverpool.
The last time Chelsea played Brighton, Sarri’s men came out on top 2-1 at the Amex Stadium thanks to goals from Pedro and Hazard.
Chelsea predicted line-up vs Brighton & Hove Albion – Premier League
(4-3-3): Arrizabalaga; Azpilicueta, Christensen, Luiz, Palmieri; Jorginho, Kante, Loftus-Cheek; Hudson-Odoi, Hazard, Giroud